Crvena Zvezda decimated Brescia at home (103-67) and secured its qualification to the Top 16.
The Serbians were unstoppable from the opening tip (31-14) and closed the first half in front by 43 points (65-22) to never look back and earn the victory.
Four players scored in double figures for the winners, with Joe Ragland having 16 points and 10 assists.
Bryon Allen had 17 points for the losing squad.
Crvena Zvezda improved to 5-4, whereas Brescia dropped to 3-6.
In the other matches, Unics Kazan (8-1) edged Unicaja Malaga (7-2) (87-84) to secure the top spot in Group D, Lokomotiv Kuban (8-1) survived Cedevita (5-4) (80-76) and Turk Telekom (4-5) beat Trento (3-6) at home (84-77).
In addition, Fraport Skyliners (6-3) defeated Mornar Bar (2-7) on the road (83-87), while Monaco (7-2) prevailed over Galatasaray (3-6) (76-71).